![]() ![]() ![]() (1991) Growth factors as morphogens: do gradients and thresholds establish body plan? Trends Genet. (1966) Le pouvoir inducteur de la chorde et du mésoblaste parachordal chez les oiseaux en fonction du facteur “temps”. (1976) From cleavage to primitive streak formation: A complementary normal table and a new look at the first stages of the development of the chick. (1991) Organizer-specific homeobox genes in Xenopus laevis embryos. (1992) Gastrulation in the mouse: the role of the homeobox gene goosecoid. Development 120: 613–620.īlum, M., Gaunt, S.J., Cho, K., Steinbeisser, H., Blumberg, B., Bittner, D. (1994) Induction of a second axis by the mouse node. This process is experimental and the keywords may be updated as the learning algorithm improves.īeddington, R.S.P. These keywords were added by machine and not by the authors. Waddington demonstrated that amniote embryos (ducks, chicks and rabbits) could also be made to generate a second nervous system by transplanting the tip of the primitive streak, a region known as Hensen’s node (Waddington, 1932 1933). This property of the amphibian dorsal lip is now widely referred to as “Spemann’s organizer”. Cells of the ectoderm of the host adjacent to the graft undergo a change in fate, from epidermal to neural. The dorsal lip of the blastopore of the gastrulating amphibian embryo is a unique region which, when transplanted to an ectopic position in a host embryo, induces the formation of a secondary embryonic axis, organised along the rostrocaudal, dorsoventral and mediolateral axes (Spemann & Mangold, 1924). ![]()
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